 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
REAGENTS |
NF-kB
DISEASES
On this page are listed several diseases in which activation of NF-kB has been implicated. For general reviews on the role of NF-kB in disease, see Aradhya & Nelson (2001), Kumar et al (2004), Yamamoto & Gaynor (2002) or Baldwin (2001). For specific diseases see the listed references, which can be found either on this site (under References) or at PubMed (through the linked references).
Disease Review/Paper
Ageing Chung et al, 2002; Adler et al, 2007; Csizar et al, 2008
Allergies Cousins et al, 2008
Headaches Reuter et al, 2003
Pain Tegeder et al, 2004; Niederberger & Geisslinger, 2008
Complex Regional Pain Syndrome Hettne et al, 2007
Cardiac Hypertrophy Purcell & Molkentin, 2003; Freund et al, 2005; Sen & Roy, 2005
Muscular Dystrophy (type 2A) Baghdiguian et al, 1999
Muscle wasting Hasselgren, 2007
Catabolic
disorders
Holmes-McNary,
2002
Diabetes,
Type 1
Ho
& Bray, 1999
Diabetes, Type 2 Yuan et al, 2001; Lehrke et al, 2004; Chen, 2005
Obesity Gil et al, 2007
Fetal Growth Retardation Mammon et al, 2005
Hypercholesterolemia Wilson et al, 2000
Atherosclerosis
Ross
et al, 2001
Heart
Disease
Valen
et al, 2001
Chronic Heart Failure Frantz et al, 2003; Gong et al, 2007
Ischemia/reperfusion Toledo-Pereyra et al, 2004; Nichols, 2004; Ridder & Schwaninger, 2008
Stroke Herrmann et al, 2005
Cerebral aneurysm Aoki et al, 2007
Angina Pectoris Ritchie, 1998
Pulmonary
Disease
Christman
et al, 2000
Cystic Fibrosis Pollard et al, 2005; Carrabino et al, 2006; Rottner et al, 2007
Acid-induced Lung Inury Madjdpour et al, 2003
Pulmonary hypertension Sawada et al, 2007
Chronic
Obstructive Pulmonary
Disease (COPD)
Barnes,
2002
Hyaline Membrane Disease Cheah et al, 2005
Kidney Disease Guijarro & Egido, 2001; Camici, 2006; Guzik & Harrison, 2007
Glomerular Disease Zheng et al, 2005
Alcoholic Liver Disease Zima & Kalousova, 2005
Leptospiriosis
renal disease
Yang
et al, 2001
Gut
Diseases
Neurath
et al, 1998
Peritoneal endometriosis Gonzalez-Ramos et al, 2007
Skin
Diseaes
Bell
et al, 2003
Nasal sinusitis Xu et al, 2006
Mesothelioma Carbone & Bedrossian, 2006
Anhidrotic Ecodermal Dysplasia-ID Puel et al, 2005
Behcet's Disease Todaro et al, 2005
Incontinentia
pigmenti
Courtois
& Israel, 2000
Tuberculosis Zea et al, 2006
Asthma
Pahl
& Szelenyi, 2002
Arthritis Roshak
et al, 2002
Crohn's
Disease
Colitis (rat) Chen et al, 2005
Ocular Allergy Bielory et al, 2002
Glaucoma Zhou et al, 2005
Appendicitis Pennington et al, 2000
Paget's Disease Lin et al, 2007
Pancreatitis Weber
& Adler, 2001
Periodonitis Nichols et al, 2001; Ambili et al, 2005
Endometriosis Guo, 2006; Celik et al, 2008
Inflammatory Bowel Disease Dijkstra et al, 2002; Atreya et al, 2008
Inflammatory Lung Disease Park & Christman, 2006
Sepsis
Wratten
et al, 2001
Silica-induced
Chen
& Shi, 2002
Sleep apnoea Lavie, 2003
AIDS
(HIV-1)
Hiscott
et al., 2001
Autoimmunity Hayashi
& Faustman, 2000
Antiphospholipid Syndrome Lopez-Pedrera et al, 2005
Lupus Kammer
& Tsokos, 2002
Lupus nephritis Zheng et al, 2006, 2008
Waldenstrom macroglobulinemia Leleu et al, 2008
Chronic Disease Syndrome Maes et al, 2007
Familial Mediterranean Fever Onen, 2005
Hereditary Periodic Fever Syndrome Jeru et al, 2008
Psychosocial stress diseases Bierhaus et al, 2004
Neuropathological
Diseases Cechetto,
2001; Mattson
& Camandola, 2001;
Pizzi
& Spano, 2006
Familial amyloidotic polyneuropathy, inflamm neuropathy Mazzeo et al, 2004
Traumatic brain injury Hang et al, 2005
Spinal cord injury Brambilla et al, 2005
Parkinson Disease Soos et al, 2004, Mogi et al, 2006
Multiple Sclerosis Satoh et al, 2007
Rheumatic Disease Okamoto, 2006; Greetham et al, 2007
Alzheimers Disease Mattson & Camandola, 2001; Collister & Albensi, 2005
Huntington's Disease Khoshnan et al, 2004
Retinal Disease Kitaoka et al, 2004
Cataracts Yang et al, 2006
Hearing loss Merchant et al, 2005; Lang et al, 2006
Cancer Gilmore
et al, 2002; Karin
et al, 2002: Lee
et al, 2007 (see Table 2, below)
______________________________________________________________________
.
Table
2:
Constitutive activation of NF-kB in human cancer cells
Cancer
type
Reference
A:
Primary tumors and tumor cell lines
Solid tumors (generally) Pacifico & Leonardi, 2006
Breast Nakshatri
et al, 1997; Sovak
et al, 1997; Ahmed
et al, 2006
Cervix Nair et al, 2003; Kumar et al, 2005; Shehata, 2005; Ramdass et al, 2006
Ovary
Dejardin
et al, 1999; Huang
et al, 2000
Vulva
Seppanen
& Vihko, 2000
Prostate Huang et al, 2001; Palayoor et al, 1999; Fradet
et al, 2004; Lessard et al, 2006; Paule et al, 2007
Bladder Horiguchi et al, 2003; Kadhim et al, 2006; Levidou et al, 2008
Lung Tichelaar et al, 2004; Tang et al, 2006; Zhang et al, 2007; Motadi et al, 2007; Stathopoulos et al, 2008
Mesothelioma Bertino et al, 2007
Non small-cell lung Zhang et al, 2006; Tew et al, 2007; Jin et al, 2008
Liver Tai et al, 2000, Arsura & Cavin, 2005; Qiao et al, 2006; Seki & Brenner, 2007
Pancreas Wang et al, 1999; Sclabas et al, 2003; Xiong, 2004; Jackson & Evers, 2006;
Zhang & Rigas, 2006; Sarkar et al, 2006; Weichert et al, 2007; Sebens et al, 2008; Holcomb et al, 2008
Esophageal/gastric Sutter et al, 2004; Lee et al, 2005; Abdel-Latif et al, 2005, 2008;
Jackson & Evers, 2006: Levidou et al, 2007
Laryngeal Zhu et al, 2004; Pan et al, 2005
Stomach Sasaki et al, 2001; Wu et al, 2007
Colon Lind et al, 2001; Schottelius & Dinter, 2006; Aranha et al, 2007
Thyroid Visconti et al, 1997; Pacifico et al, 2004; Gombos et al, 2007
Parathyroid Corbetta et al, 2004
Melanoma Yang & Richmond, 2001; Torabian & Kashani-Sabet, 2005;
Amiri & Richmond, 2005; Ueda & Richmond, 2006; Van den Oord et al, 2007
Squamous cell carcinoma Loercher et al, 2004; Kobielak & Fuchs, 2006
Head and neck Ondrey et al, 1999; Chung et al, 2006; Allen et al, 2007
Jackson-Bernitsas et al, 2007;
Endometrial (Uteris) Pallares et al, 2004; Domenyuk et al, 2007
Cylindromatosis Kovalenko et al, 2003; Brummelkamp et al, 2003; Trompouki et al, 2003
Brooke-Spiegler, Trichoepithelioma Almeida et al, 2007
Hilar Cholangiocarcinoma Chen et al, 2005
Oral
carcinoma Nakayama
et al, 2001; Bindhu
et al, 2006; Mishra
et al, 2006; Sawhney
et al, 2007
Min et al, 2007
Astrocytoma/glioblastoma Hayahsi et al, 2001; Garkavtsev et al, 2004
Neuroblastoma Bian et al, 2002; Brown et al, 2007; Widera et al, 2007
Glioblastoma Raychaudhuri et al, 2007; Smith et al, 2007
Hodgkin’s
lymphoma
Bargou
et al, 1996, 1997;
Staudt,
2000
Acute lymphoblastic leukemia Kordes et al, 2000; Munzert et al, 2004
Acute
myelogenous leukemia
Guzman
et al, 2001; Fabre
et al, 2007
Acute
T-cell leukemia (+/-HTLV-1)
Arima
& Tei, 2001; Horie
et al, 2006
Acute Non-lymphocytic leukemia Lei & Zhao, 2007
Chronic
lymphocytic leukemia Furman
et al, 2000
Burkitts
Lymphoma (EBV)
Knecht
et al, 2001
Mantle cell lymphoma Martinez et al, 2003
Myelodysplastic syndrome Fabre et al, 2007
Multiple myeloma Berenson et al, 2001; Gilmore, 2007
Diffuse
large B-cell lymphoma
Davis
et al, 2001; Shaffer
et al, 2002
MALT lymphoma Sagaert al, 2007; Inagaki, 2007; Du, 2007
B:
In vitro transformation of cells
AP12/MALT1 Stoffel et al, 2004; Ho et al, 2005; Lucas et al, 2007
BCR-ABL
Reuther
et al, 1999
BRAF Liu et al, 2007
DBL/DBS
Whitehead
et al, 1999
Muc1 Ahmad et al, 2007
Notch1 Vilimas et al, 2006
Pim-2 Fox et al, 2003; Hammerman et al, 2004
PDGF-beta chain Shimamura et al, 2002
RAF
Baumann
et al, 2000
RAS
Finco
et al, 1997
RET/PTC3
Russell
et al, 2003
TEL-JAK2
Santos
et al, 2001
TEL-PDGFR
Besancon
et al, 1998
Tio
(herpesvirus)
Heinemann
et al, 2006
Vav
Palmby
et al, 2004
______________________________________________________________________
Reference
List
Abdel-Latif MM, Kelleher D and Reynolds JV (2008) Potential role of NF-kB in esophageal adenocarcinoma: as an emerging molecular target. Journal of Surgical Research in press
Abdel-Latif MM, O'Riordan JM, Ravi N, Kelleher D and Reynolds JV (2005) Activated nuclear factor-k B and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy. Diseases of Esophagus 18: 246-252
Abraham E (2003) Nuclear factor-kB and its role in sepsis-associated organ failure. Journal of Infectious Diseases 187: S364-S369
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E and Chang HY (2007) Motif module map reveals enforcement of aging by continual NF-kB activity. Genes & Development, in press
Ahmed KM, Cao N and Li JJ (2006) HER-2 and NF-kB as the targets for therapy-resistant breast cancer. Anticancer Research 26: 4235-4243
Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S and Kufe D (2007) MUC1 oncoprotein activates the IkB kinase beta complex and constitutive NF-kB signaling. Nature Cell Biology in press
Allen CT, Ricker JL, Chen Z and Van Waes C (2007) Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck.. Head & Neck 29: 959-971
Almaeda S, Maillard C, Itin P, Hohl D and Huber M (2007) Five new CYLD mutations in skin appendage tumors and evidence that aspartic acid 681 in CYLD is essential for deubiquitinase activity. Journal of Investigative Dermatology, in press
Ambili R, Santhi WS, Janam P, Nandakumar K and Pillai MR (2005) Expression of activated transcription factor nuclear factor-kB in periodontally diseased tissues. Journal of Periodontology 76: 1148-1153
Amiri KI and Richmond A (2005) Role of nuclear factor-kB in melanoma. Cancer Metastasis Reviews 24: 301-313
Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R and Hashimoto N (2007) NF-kB is a key mediator of cerebral aneurysm formation. Circulation in press
Aradhya S and Nelson DL (2001) NF-kB
signaling and human disease. Current
Opinions in Genetics and Development 11: 300-306
Aranha MM, Borralho PM, Ravasco P, Moreira da Silva IKB, Correia L, Fernandes A, Camilo ME and Rodrigues CM (2007) NF-kB and apoptosis in colorectal tumourigenesis. European Journal of Clinical Investigation 37: 416-424
Arima N and Tei C (2001) HTLV-I Tax related dysfunction of cell cycle regulators and oncogenesis of adult T cell leukemia. Leukemia and Lymphoma 40: 267-278 Leukemia and Lymphoma 40: 267-278
Arsura M and Cavin LG (2005) Nuclear factor-kB and liver carcinogenesis. Cancer Letters 229: 157-169
Atreya I, Atreya R and Neurath MF (2008) NF-kB in inflammatory bowel disease. Journal of Internal Medicine 263: 591-596
Aud D and Peng SL (2006) Mechanisms of disease: transcription factors in inflammatory arthritis. Nature Clinical Practice: Rheumatology 2: 434-442
Bacher S and Schmitz ML (2004) The NF-kB pathway as a potential target for autoimmune disease therapy. Current Pharmeutical Design 10: 2827-2837
Baghdiguian S, Martin M, Richard I, Pons F, Astier C, Bourg N,
Hay RT, Chemaly R, Halaby G, Loiselet J, Anderson LV, Lopez de Munain A,
Fardeau M, Mangeat P, Beckmann JS and Lefranc G (1999) Calpain 3
deficiency is associated with myonuclear apoptosis and profound
perturbation of the IkB alpha/NF-kB pathway in limb-girdle muscular
dystrophy type 2A . Nature Medicine 5: 503-511
Baldwin AS Jr (2001) Series introduction: the transcription factor NF-kB and human disease. Journal of Clinical Investigation 107: 3-6
Bargou
RC, Leng C, Krappmann D, Emmerich F, Mapara MY, Bommert K, Royer H-D,
Scheidereit C and Dörken (1996) High-level nuclear NF-kB and Oct-2 is a
common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 87:
4340-4347
Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W, Royer HD, Grinstein E, Greiner A, Scheidereit C and Dörkin B (1997) Constitutive NF-kB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. Journal of Clinical Investigation 100: 2961-2969
Barnes
PJ (2002) New treatments for COPD. Nature Reviews Drug Discovery 1:
437-446
Baumann
B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR and Wirth T
(2000) Raf induces NF-kB by membrane shuttle kinase MEKK1, a signaling
pathway critical for transformation. Proceedings of the National Academy
of Sciences USA 97: 4615-4620
Bell
S, Degitz K, Quirling M, Jilg N, Page S and Brand K (2003) Involvement
of NF-kB signalling in skin physiology and disease. Cell
Signaling 15: 1-7
Berenson JR, Ma HM and Vescio R (2001) The role of nuclear factor-kB in
the biology and treatment of multiple myeloma. Seminars in Oncology 28:
626-633
Bertino P, Marconi A, Palumbo L, Bruni BM, Barbone D, Germano S, Dogan AU, Tassi GF, Porta C, Mutti L and Gaudino G (2007) Erionite and asbestos differently cause transformation of human mesothelial cells. International Journal of Cancer 121: 2766-2774
Besancon F, Atfi A, Gespach C, Cayre YE and Bourgeade MF (1998) Evidence for a role of NF-kB in the survival of hematopoietic cells mediated by interleukin-3 and the oncogenic TEL/platelet-derived growth factor beta fusion protein. Proceedings of the National Academy of Sciences USA 95: 8081-8086
Bian X, Opipari Jr AW, Ratanaproeksa AB, Boltano AE, Lucas
PC and Castle VP (2002) Constitutively active NF-kB is required for the
survival of S-type neuroblastoma. Journal of Biological Chemistry 277:
42144-42150
Bielory L, Kempuraj D and Theoharides T (2002) Topical immunopharmacology of ocular allergies. Current Opinion in Allergy and Clinical Immunology 2: 435-445
Bierhaus A, Humpert PM and Nawroth PP (2004) NF-kB as a molecular link between psychosocial stress and organ dysfunction. Pediatic Nephrology 19: 1189-1191
Bindhu OS, Ramadas K, Sebastian P and Pillai MR (2006) High expression levels of nuclear factor kB and gelatinases in the tumorigenesis of oral squamous cell carcinoma. Head and Neck 28: 916-925
Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ and Bethea JR (2005) Inhibition of astroglial nuclear factor kB reduces inflammation and improves functional recovery after spinal cord injury. Journal of Experimental Medicine 202: 145-156
Brown RE, Tan D, Taylor JS, Miller M, Prichard JW and Kott MM (2007) Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kB pathways in high risk neuroblastoma, with cell cycle and protein analyte correlates. Annals of Clinical and Laboratory Science 37: 141-147
Brummelkamp TR, Nijman SMB, Cirac AMG and Bernards R (2003) Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kB. Nature 424: 797-801
Camici M (2007) The Nephrotic Syndrome is an immunoinflammatory disorder. Medical Hypotheses 68: 900-905
&nb